Poppy seeds do have small amounts of opium content and eating poppy seeds may rarely yield a positive result on drug tests. Usually, most of the opium is removed from the poppy seeds during processing. However, according to the U.S. Anti-Doping Agency (USADA), drug testing will account for the morphine threshold level. According to the USADA, morphine and codeine may be detected in the urine up to 2 days after consuming poppy seeds from baked items such as pastries, bagels, muffins, and cakes. WADA-accredited laboratories mark a urine sample as positive for morphine when the level exceeds 1.3 micrograms/mL. World Health Organisation. Information sheet on opioid overdose Online: World Health Organisation; 2018 If your use of opium is affecting your health, family, relationships, work, school, financial or other life situations, or you’re concerned about a loved one, you can find help and support. Derks, Hans: History of the Opium Problem: The Assault on the East, ca. 1600–1950. Sinica Leidensia, 105. Leiden: Brill, 2012. ISSN 0169-9563. ISBN 978-90-04-22158-1

Karl A. Sporer, M.D. (April 6, 1999). "Acute Heroin Overdose". Annals of Internal Medicine. 130 (7): 584–590. doi: 10.7326/0003-4819-130-7-199904060-00019. PMID 10189329. S2CID 22949289.a b c d e Alfred W. McCoy. "Opium History, 1858 to 1940". Archived from the original on April 4, 2007 . Retrieved May 4, 2007. Withdrawal symptoms usually start six to 24 hours after the last dose and can last around seven to ten days. These symptoms are described as flu-like, and can include: Presley CC, Lindsley CW. DARK Classics in Chemical Neuroscience: opium, a historical perspective. ACS Chemical Neuroscience. 2018;9(10):2503-18.

The Greek gods Hypnos (Sleep), Nyx (Night), and Thanatos (Death) were depicted wreathed in poppies or holding them. Poppies also frequently adorned statues of Apollo, Asclepius, Pluto, Demeter, Aphrodite, Kybele and Isis, symbolizing nocturnal oblivion. [1] Islamic societies (500–1500 CE) [ edit ] Opium users in Java during the Dutch colonial period, c. 1870 Pablo Bartholomew (1996). "Opium for the masses: photo essay on cultivation of opium in India". Archived from the original on July 1, 2007 . Retrieved June 15, 2007. The use of diethyl ether and chloroform for general anesthesia began in 1846–1847, and rapidly displaced the use of opiates and tropane alkaloids from Solanaceae due to their relative safety. [103]

Paul Harris in Peshawar (November 25, 2001). "Victorious warlords set to open the opium floodgates". London: Observer.guardian.co.uk . Retrieved March 21, 2010. In the U.S. in the 1800's, opium dens sprang up in the west, such as in San Francisco's Chinatown, and spread east to New York. Chinese immigrants who came to the U.S. for railroad and the gold rush work often brought their opium with them for its intoxicating and pain-relieving effects.

Hideyuki Takano; The Shore Beyond Good and Evil: A Report from Inside Burma's Opium Kingdom (2002, Kotan, ISBN 0-9701716-1-7)Robinson SL, Rowbotham DJ, Smith G (July 1991). "Morphine compared with diamorphine. A comparison of dose requirements and side-effects after hip surgery". Anaesthesia. 46 (7): 538–40. doi: 10.1111/j.1365-2044.1991.tb09650.x. PMID 1862890. S2CID 35289009. In 2021, the International Agency for Research on Cancer concluded that opium is a Group 1 (sufficient evidence) human carcinogen, causing cancers of the larynx, lung, and urinary bladder. [157] Slang terms [ edit ] Finn AK, Whistler JL (December 2001). "Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal". Neuron. 32 (5): 829–39. doi: 10.1016/S0896-6273(01)00517-7. PMID 11738029. S2CID 16396686.

Abu Bakr Muhammad ibn Zakariya al-Razi (841–926)". Saudi Aramco World. January 2002 . Retrieved January 12, 2008.

For the illegal drug trade, the morphine is extracted from the opium latex, reducing the bulk weight by 88%. It is then converted to heroin which is almost twice as potent, [6] and increases the value by a similar factor. The reduced weight and bulk make it easier to smuggle. Great Britain (1913). Agreement between Great Britain and Portugal for regulation of the opium monopolies of the colonies of Hong Kong and Macao. London, Printed for H.M. Stationery office. by Harrison and sons, ltd.